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T Koike Selected Research

4- ((2- amidino- 1,2,3,4- tetrahydroisoquinolin- 7- yloxy)methyl)- 1- (4- pyridinyl)piperidine- 4- carboxylic acid monomethanesulfonate trihydrate

4/2004Synthetic selective inhibitors of coagulation factor Xa strongly inhibit thrombin generation without affecting initial thrombin forming time necessary for platelet activation in hemostasis.

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T Koike Research Topics

Disease

18Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome)
01/2021 - 01/2000
13Thrombosis (Thrombus)
01/2021 - 01/2000
10Infections
11/2008 - 01/2000
6Atherosclerosis
07/2013 - 10/2000
6Insulin Resistance
04/2012 - 02/2000
6Neoplasms (Cancer)
07/2008 - 09/2000
5Necrosis
07/2010 - 03/2000
4Gastroesophageal Reflux (GERD)
01/2021 - 07/2007
4Rheumatoid Arthritis
02/2016 - 04/2001
4Aplastic Anemia (Anemia, Hypoplastic)
08/2011 - 10/2001
4Non-Hodgkin Lymphoma (Lymphosarcoma)
03/2005 - 08/2000
3Obesity
03/2011 - 02/2000
3Atrophy
10/2009 - 03/2005
3Type 2 Diabetes Mellitus (MODY)
07/2009 - 05/2001
3Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
09/2008 - 01/2000
3Residual Neoplasm
03/2005 - 01/2000
3Leukemia
07/2004 - 04/2000
2Autoimmune Diseases (Autoimmune Disease)
01/2021 - 06/2000
2Hypertrophy
01/2021 - 10/2009
2Connective Tissue Diseases (Connective Tissue Disease)
10/2011 - 06/2009
2Myelodysplastic Syndromes (Myelodysplastic Syndrome)
07/2011 - 04/2000
2Lung Neoplasms (Lung Cancer)
06/2009 - 04/2001
2Wallerian Degeneration
07/2007 - 01/2003
2Cushing Syndrome
01/2007 - 06/2001
2Systemic Scleroderma (Systemic Sclerosis)
08/2006 - 08/2005
2Pathologic Complete Response
06/2005 - 08/2004
2Stomach Ulcer (Gastric Ulcer)
03/2005 - 01/2000
2Thrombocytopenia (Thrombopenia)
01/2005 - 11/2000
2Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune)
01/2005 - 11/2000
2Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
08/2004 - 07/2004
2Diabetes Mellitus
10/2001 - 12/2000
2Disease Progression
10/2001 - 06/2000
2Hematologic Neoplasms (Hematological Malignancy)
06/2001 - 11/2000
2Pleurisy (Pleuritis)
04/2001 - 01/2000
2Systemic Lupus Erythematosus (Libman-Sacks Disease)
04/2001 - 12/2000
2Hepatitis B
02/2001 - 04/2000
2Adenocarcinoma
01/2001 - 01/2000
2Myeloproliferative Disorders (Myeloproliferative Disorder)
06/2000 - 04/2000
1Bone Resorption
02/2016
1Eosinophilia
04/2015
1Laryngeal Edema
01/2013
1Esophageal Squamous Cell Carcinoma
01/2013
1Squamous Cell Carcinoma of Head and Neck
01/2013

Drug/Important Bio-Agent (IBA)

12AntibodiesIBA
10/2014 - 01/2000
9Antiphospholipid AntibodiesIBA
07/2006 - 01/2000
6Proteins (Proteins, Gene)FDA Link
01/2021 - 01/2000
6Lupus Coagulation Inhibitor (Lupus Anticoagulant)IBA
10/2014 - 03/2000
5PhosphatidylserinesIBA
10/2014 - 09/2000
5Anticardiolipin AntibodiesIBA
04/2010 - 01/2000
5AcidsIBA
07/2007 - 01/2000
4beta 2-Glycoprotein I (Apolipoprotein H)IBA
01/2021 - 10/2000
4Prothrombin (Factor II)IBA
10/2014 - 09/2000
4EnzymesIBA
01/2007 - 05/2001
4oxidized low density lipoproteinIBA
01/2003 - 10/2000
4Immunoglobulin G (IgG)IBA
03/2002 - 12/2000
3AntigensIBA
01/2021 - 05/2001
3GastrinsIBA
01/2021 - 01/2000
3Proton Pump InhibitorsIBA
01/2021 - 07/2007
3Insulin (Novolin)FDA Link
04/2012 - 01/2001
3Pharmaceutical PreparationsIBA
07/2009 - 03/2001
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/2008 - 05/2001
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
08/2005 - 12/2000
3Rituximab (Mabthera)FDA Link
06/2005 - 02/2004
3Phospholipids (Phosphatides)FDA LinkGeneric
09/2001 - 01/2000
2FructoseIBA
04/2012 - 08/2008
2Infliximab (Remicade)FDA Link
07/2010 - 02/2008
2Glucose (Dextrose)FDA LinkGeneric
07/2009 - 07/2004
2Cisplatin (Platino)FDA LinkGeneric
09/2008 - 10/2000
2Docetaxel (Taxotere)FDA Link
09/2008 - 08/2000
2AnticoagulantsIBA
01/2007 - 03/2002
2Pepsinogen A (Pepsinogen)IBA
03/2005 - 04/2003
2Etoposide (VP 16)FDA LinkGeneric
08/2004 - 10/2000
2SteroidsIBA
08/2003 - 04/2000
2Vinblastine (Vinblastine Sulfate)FDA Link
01/2003 - 10/2000
2ImmunosorbentsIBA
09/2001 - 05/2001
2Mannose-Binding Lectin (Mannan-Binding Lectin)IBA
04/2001 - 09/2000
1Tyrosine (L-Tyrosine)FDA Link
01/2021
1Eicosapentaenoic AcidIBA
01/2021
1Collagen Type I (Type I Collagen)IBA
02/2016
1collagen type I trimeric cross-linked peptideIBA
02/2016
1OsteocalcinIBA
02/2016
1GlucocorticoidsIBA
02/2016
1LigandsIBA
07/2013
1Scavenger Receptors (Scavenger Receptor)IBA
07/2013
1Glycoproteins (Glycoprotein)IBA
07/2013
1candesartan cilexetil (Amias)FDA Link
04/2012
1Angiotensin II Type 1 Receptor BlockersIBA
04/2012
1Adrenal Cortex Hormones (Corticosteroids)IBA
10/2011

Therapy/Procedure

11Therapeutics
01/2021 - 06/2000
8Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation)
06/2005 - 04/2000
7Stem Cell Transplantation
10/2010 - 10/2001
7Drug Therapy (Chemotherapy)
09/2008 - 06/2000
5Transplantation
08/2011 - 01/2004
3Radiotherapy
01/2013 - 10/2000
3Bone Marrow Transplantation (Transplantation, Bone Marrow)
10/2010 - 04/2000
3Segmental Mastectomy (Lumpectomy)
06/2009 - 04/2001
3Hematopoietic Stem Cell Transplantation
08/2004 - 12/2000
3Thoracotomy
04/2001 - 01/2000
2Organ Transplantation
12/2000 - 04/2000
1Neck Dissection (Radical Neck Dissection)
01/2013